Gull in Sunset. Rovinj, Croatia.
Sep 2009. (c) Copyright 2009 by
A. Avdeef.


ABOUT in-ADME Research

in-ADME Research was founded in 2011, and has been responsible for providing unique software products and expert consulting services. Our specialty is in PHYSICOCHEMICAL PROFILING (solubility, dissolution, permeability, pKa/pH) applied to discovery and early development of drugs in pharmaceutical R&D. Our customers & clients value our expertise, something we have been collectively nourishing for nearly forty years.

The critical knowledge base for in-ADME Research has been summarized in the book written by one of the principals: Absorption and Drug Development Second Edition, Wiley, 2012. It serves as a unique resource and explores in depth the relationships between the ionization constant, solubility, and permeability as a function of pH, and applies this to the prediction of drug absorption and distribution into the brain.

      Transport factors underlying human permeability. Avdeef A, Tam KY. J. Med. Chem. 2010, 53, 3566-3584.