Gull in Sunset. Rovinj, Croatia.
Sep 2009. (c) Copyright 2009 by
A. Avdeef.


Absorption and Drug Development

Second Edition, Wiley, 2012 (ISBN 978-1-1180-5745-2)

Absorption and Drug Development (744 pages) will continue to serve the needs of pharmaceutical R&D as a reference and supplemental textbook on physical property measurement and interpretation (pH, pKa, log P, log D, solubility, PAMPA, Caco-2/MDCK, and blood-brain barrier permeability). Physical/analytical chemists in pharma companies and at the universities who measure the physical properties of complicated (e.g., practically-insoluble or multiply-ionizable) small molecules, and chemists who synthesize molecules with optimal physical properties and the biologist who apply improved cellular assays to profile these molecules could benefit from the insights provided in the book. Due to its in-depth coverage of fundamental principles and its many property and equation tables, Absorption and Drug Development is expected to be useful resource for some time.

Extensive Data Tables for Computational Chemists

Novel Analysis

The in vitro cellular measurements based on the analysis of permeability in terms of the Dynamic Range Window (transcellular, aqueous boundary layer, and paracellular) biophysical model is unique.  The new flow correction (pH-dependent Crone-Renkin equation) method for in situ brain perfusion can expand the dynamic range of BBB permeability measurements.  The coverage of pKa determination is perhaps the deepest ever published.  Origin-shifted Yasuda-Shedlovsky and in situ electrode calibration analysis applied to determining ionization constants of practically insoluble molecules is novel. (The author is one of the last standing old-school experts in pKa analysis.)  The use of cellular biophysical models directly to predict human jejunal permeability is new.  The analysis of solubility is mathematically comprehensive.  The PAMPA coverage is extensive – with several variants discussed in detail.  The Principal has the highest number of PAMPA primary publications of any author.

Educational Resource

Although not specifically designed for the purpose, the book can be used as a supplemental text in graduate courses in preformulation or related physicochemical sciences, with focus on the absorption/distribution part of ADME (absorption, distribution, metabolism, elimination). The book could be used as part of an Advanced Physical Pharmacy and Pharmaceutics course, supplementing and expanding on, for example, Sinko, PJ. Martin’s Physical Pharmacy and Pharmaceutical Sciences. 5th Ed. Lippincott Williams & Wilkins (2006).


Absorption and Drug Development, Second Edition, 2012